解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Clopidogrel (INN), an oral antiplatelet drug, has been revealed to have a number of biological properties, for instance, anti-inflammation and antioxidation. Oxidative stress plays an imperative role in inflammation, diabetes mellitus, atherosclerosis, and cancer. In the present study, human aortic endothelial cells (...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9128050
更新日期:2016-01-01 00:00:00
abstract::In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical. However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments. The aim ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3615286
更新日期:2016-01-01 00:00:00
abstract::Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to p...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1786789
更新日期:2016-01-01 00:00:00
abstract::A growing body of evidence suggests yogic practices may benefit adults with type 2 diabetes (DM2). In this systematic review, we evaluate available evidence from prospective controlled trials regarding the effects of yoga-based programs on specific health outcomes pertinent to DM2 management. To identify qualifying st...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/6979370
更新日期:2016-01-01 00:00:00
abstract::Background. The aim of this study was to validate the impact of type 2 diabetes (T2D) on the platelet reactivity in patients with acute ST elevation myocardial infarction (STEMI) treated with adenosine diphosphate (ADP) receptor blockers. Methods. A pilot prospective study was performed. Totally 67 patients were enrol...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2909436
更新日期:2016-01-01 00:00:00
abstract::Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM pa...
journal_title:Journal of diabetes research
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/5928726
更新日期:2016-01-01 00:00:00
abstract::Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive c...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3047574
更新日期:2016-01-01 00:00:00
abstract::Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients. A multifaceted treatment approach can include nutritional supplements with antioxidant properties such as 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC). This prospective, randomized, sing...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/8294805
更新日期:2016-01-01 00:00:00
abstract::Macrophage migration inhibitory factor (Mif) is highly expressed in type 1 diabetes mellitus (T1DM). However, there is limited information about how Mif influences the activation of macrophages (Mφ) and dendritic cells (DC) in T1DM. To address this issue, we induced T1DM by administering multiple low doses of streptoz...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7053963
更新日期:2016-01-01 00:00:00
abstract::Previous study demonstrated that Chang Run Tong (CRT) could partly restore the colon remodeling in streptozotocin- (STZ-) induced diabetic rats. Here we investigated the mechanisms of such effects of CRT. Diabetes was induced by a single injection of 40 mg/kg of STZ. CRT was poured into the stomach by gastric lavage o...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1826281
更新日期:2016-01-01 00:00:00
abstract::Metabolic memory (MM) is defined as the persistence of diabetic (DM) complications even after glycemic control is pharmacologically achieved. Using a zebrafish diabetic model that induces a MM state, we previously reported that, in this model, tissue dysfunction was of a heritable nature based on cell proliferation st...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/2860780
更新日期:2016-01-01 00:00:00
abstract::Introduction. Diabetic Ketoacidosis (DKA) is a serious complication that can be life-threatening. Management of DKA needs admission in a specialized center and imposes major constraints on hospital resources. Aim. We plan to study the impact of adapting a diabetes-educator care model on reducing the frequency of hospi...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3917806
更新日期:2016-01-01 00:00:00
abstract::Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/5263798
更新日期:2016-01-01 00:00:00
abstract::Insulin resistance plays a key role in the development of type 2 diabetes. It arises from a combination of genetic predisposition and environmental and lifestyle factors including lack of physical exercise and poor nutrition habits. The increased risk of type 2 diabetes is molecularly based on defects in insulin signa...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/2868652
更新日期:2016-01-01 00:00:00
abstract::According to the American Diabetes Association (ADA), the side effects of diabetes mellitus have recently increased the global health expenditure each year. Of these, the early diagnostic can contribute to the decrease on renal, cardiovascular, and nervous systems complications. However, the diagnostic criteria, which...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8483537
更新日期:2016-01-01 00:00:00
abstract::Native Hawaiians and other Pacific Islanders (NH/PI; e.g., Samoan and Chuukese) have higher type 2 diabetes prevalence compared to other groups in Hawai'i. Partners in Care (PIC), a culturally tailored, community-based, diabetes self-management education intervention (DSME), is effective at improving participants' gly...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/7913258
更新日期:2016-01-01 00:00:00
abstract::With-no-lysine (K) Kinase-4 (WNK4) consisted of unique serine and threonine protein kinases, genetically associated with an autosomal dominant form of hypertension. Argumentative consequences have lately arisen on the association of specific single nucleotide polymorphisms of WNK4 gene and essential hypertension (EHT)...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8219543
更新日期:2016-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) agonists are used for treating hyperglycemia and type 2 diabetes. However, the mechanism of action of these agonists is still under investigation. The lipid droplet-associated proteins FSP27/CIDEC and LSDP5, regulated directly by PPARγ and PPARα, are associated with he...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8315454
更新日期:2016-01-01 00:00:00
abstract::Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since pumps provide ...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/8310516
更新日期:2016-01-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. METHOD:The study group consisted of 426 children aged 0-18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9582793
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of onsite screening with a nonmydriatic, digital fundus camera for diabetic retinopathy (DR) at a diabetes outpatient clinic. RESEARCH DESIGN AND METHODS:This cross-sectional study included 502 patients, 112 with type 1 and 390 with type 2 diabetes. Patients attended screenings for mic...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/4101890
更新日期:2016-01-01 00:00:00
abstract::The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes. Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species. The (-)-epigallocatechin gallate (EGCG) is considered...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/1867059
更新日期:2016-01-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is characterized by a metabolic shift from fat to carbohydrates and failure to increase myocardial glucose uptake in response to workload increments. We verified whether this pattern is influenced by an abnormal glucose tolerance (AGT). In 10 patients with DCM, 5 with normal glucose tolera...
journal_title:Journal of diabetes research
pub_type: 临床试验,杂志文章
doi:10.1155/2016/3906425
更新日期:2016-01-01 00:00:00
abstract::The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2016/4270301
更新日期:2016-01-01 00:00:00
abstract::Background. There are different metabolic syndrome traits among patients with different ethnicities. Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metabolic syndrome (MetS) and Type 2 Diabetes (T2D). Insulin sensitivity ind...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/9286303
更新日期:2016-01-01 00:00:00
abstract::Aim. To investigate corneal endothelial cell morphological in children with type 1 diabetes and to determine the systemic and local factors that contribute to these changes. Methods. One hundred sixty eyes of 80 children with type 1 diabetes and 80 eyes of 40 normal children as a control during the period from July 20...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/7319047
更新日期:2016-01-01 00:00:00
abstract::Background/Aims. Subclinical atherosclerosis and long-term glycemic variability have been reported to predict incident chronic kidney disease (CKD) in the general population. However, these associations have not been investigated in patients with type 2 diabetes with preserved kidney function. Methods. We prospectivel...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/3295747
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy. METHODS:We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retino...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2016/6156217
更新日期:2016-01-01 00:00:00
abstract::We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5027356
更新日期:2016-01-01 00:00:00
abstract::Diabetic encephalopathy is a diabetic complication related to the metabolic alterations featuring diabetes. Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy rema...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/485759
更新日期:2015-01-01 00:00:00
abstract::Partial or complete remission from type 2 diabetes was recently observed after bariatric surgeries. Limited data is available about the possibility of inducing diabetes remission through intensive weight reduction. We retrospectively evaluated diabetes remissions after one year of the Weight Achievement and Intensive ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/468704
更新日期:2015-01-01 00:00:00
abstract::The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis induced by high glucose. Mevalonate pathway is an important metabolic pathway that plays a key role in multiple cellular processes. The aim of this study was to define whether the enzyme expression in mevalonate pa...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/379287
更新日期:2015-01-01 00:00:00
abstract::Statin therapy improves lipid profiles and reduces vascular inflammation, but its effects on central arterial stiffness in type 2 diabetes are unclear. The aim of this study was to determine whether statin therapy reduces central arterial stiffness, in a dose-dependent manner, in male patients with type 2 diabetes. Fi...
journal_title:Journal of diabetes research
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/846807
更新日期:2015-01-01 00:00:00
abstract::Most patients with type 2 diabetes (T2D) have suboptimal adherence to recommended diet, physical activity, and/or medication. Current approaches to improve health behaviors in T2D have been variably effective, and successful interventions are often complex and intensive. It is therefore vital to develop interventions ...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/428349
更新日期:2015-01-01 00:00:00
abstract:AIMS AND BACKGROUND:Type 2 diabetes is a chronic disease that cannot be treated adequately using the known monotherapies, especially when the disease progresses to an advanced stage. In this study, we explore the possibility of treating the disease with a novel combination approach of oleanolic acid (OA), a glycogen ph...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/973287
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β-cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enrolled in this study. Venous blood samples were collected at 0 min, 30 min, and 120 m...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/636891
更新日期:2015-01-01 00:00:00
abstract:AIMS:This study assesses the impact of using an AP-system at home on fear of hypoglycaemia. In addition, satisfaction and acceptance of the new technology are evaluated. METHODS:In a multicentre, multinational study of 75 patients using the MD-Logic AP during four consecutive nights in home setting 59 of them (aged 10...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/590308
更新日期:2015-01-01 00:00:00
abstract::T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. Whether induced T2DM and T1DM differently affect the gastric GLP-1R expression is not known. This study assessed extrapancreatic GLP-1R system in glandular stomach of rodents with different types of experimental diabetes. T2D...
journal_title:Journal of diabetes research
pub_type: 杂志文章
doi:10.1155/2015/561353
更新日期:2015-01-01 00:00:00
abstract::Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascu...
journal_title:Journal of diabetes research
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/613860
更新日期:2015-01-01 00:00:00
abstract::Probably, the most paradigmatic example of diabetic complication is diabetic nephropathy, which is the largest single cause of end-stage renal disease and a medical catastrophe of worldwide dimensions. Metabolic and hemodynamic alterations have been considered as the classical factors involved in the development of re...
journal_title:Journal of diabetes research
pub_type: 杂志文章,评审
doi:10.1155/2015/948417
更新日期:2015-01-01 00:00:00